Galectin-3 and N-acetylglucosamine promote myogenesis and improve skeletal muscle function in the mdx model of Duchenne muscular dystrophy
نویسندگان
چکیده
Glycobiology and Bioimaging Laboratory, Research Centre for Infectious Diseases, Faculty of Medicine, Laval University, Quebec City, Canada Research Centre of CHU de Québec, and Department of Rehabilitation, Faculty of Medicine, Laval University, Quebec City, Canada Bioimaging Platform, Research Centre of CHU de Québec, Quebec City, Canada Laboratory of DNA Damage Responses and Bioimaging, Research Centre of CHU de Québec, Faculty of Medicine, Laval University, Quebec City, Canada The present address is Unité d’enseignemnt en phsiothérapie, Université du Québec à Chicoutimi
منابع مشابه
Muscular dystrophy begins early in embryonic development deriving from stem cell loss and disrupted skeletal muscle formation.
Examination of embryonic myogenesis of two distinct, but functionally related, skeletal muscle dystrophy mutants (mdx and cav-3(-/-)) establishes for the first time that key elements of the pathology of Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophy type 1C (LGMD-1c) originate in the disruption of the embryonic cardiac and skeletal muscle patterning processes. Disruption o...
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Duchenne muscular dystrophy (BMD) is an inherited X-link disease. The incidence of this muscle-wasting disease is 1:5000 male live births. Mutation in the gene coding for dystrophin is the main cause of BMD. Most cases of this disease succumb to respiratory and cardiac failure in 3rd to 4th decades. The slow progression of BMD and recent achievement of gene therapies make it as an appropriate c...
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Muscle degenerative diseases such as Duchenne Muscular Dystrophy are incurable and treatment options are still restrained. Understanding the mechanisms and factors responsible for muscle degeneration and regeneration will facilitate the development of novel therapeutics. Several recent studies have demonstrated that Galectin-1 (Gal-1), a carbohydrate-binding protein, induces myoblast differenti...
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Duchenne muscular dystrophy is a very severe muscle disease that is characterized by progressive skeletal muscle wasting. Duchenne muscular dystrophy is provoked by mutations in the gene encoding the protein dystrophin, which lead to the total absence of this protein in skeletal muscles. In normal skeletal muscle, dystrophin is located underneath the sarcolemma, and interacts with the F-actin c...
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Skeletal muscle injury activates adult myogenic stem cells, known as satellite cells, to initiate proliferation and differentiation to regenerate new muscle fibers. The skeletal muscle-specific microRNA miR-206 is upregulated in satellite cells following muscle injury, but its role in muscle regeneration has not been defined. Here, we show that mi...
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